Open Conference Systems, DDAYS LAC 2024 Main Conference

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Temporal and Spatial Evolution of Neuronal Dynamics in Alzheimer's Disease: An Information Theory Perspective
Federico Miceli, Mauro Granado, Marcelo A Montemurro, Fernando Montani

Building: Cero Infinito
Room: Posters hall
Date: 2024-12-10 04:30 PM – 06:30 PM
Last modified: 2024-11-19

Abstract


Cognitive function steadily declines as a result of Alzheimer's disease (AD), a neurodegenerative condition. We must employ scientific study to learn more about the mechanisms underlying AD as there is now no therapy for the condition. A number of brain regions, including association areas, limbic system regions linked to emotion and memory, and memory itself, are commonly seen to be degenerating. The central nervous systems of people with Alzheimer's disease (AD) undergo a buildup of the illness's pathology. This accumulation generally follows a distinct pattern in terms of place and duration. We compare the dynamics of healthy tissues with the evolution of complexity and Shannon entropy for various stages of Alzheimer's disease in mice using information theory methods.Our research allows us to hypothesize on potential indicators of Alzheimer's disease by demonstrating how neuronal dynamics change over the course of months in terms of both  spatial and temporal domains.